Acetylcysteine Ph. Eur.
Acetylcysteine is also known as N-acetylcysteine or N-acetyl-L-cysteine or NAC. It is the N-acetyl derivative of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase 1) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores. Acetylcysteine can also be used as a general antioxidant which can help mitigate symptoms for a variety of diseases exacerbated by reactive oxygen species (ROS).
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| CAT# | 10-101-106 |
| CAS | 616-91-1 |
| Synonyms/Alias | N-Acetyl-L-cysteine; NAC; L-α-Acetamido-β-mercaptopropionic acid; NSC-111180 |
| Chemical Name | (2R)-2-acetamido-3-sulfanylpropanoic acid |
| M.F/Formula | C5H9NO3S |
| M.W/Mr. | 163.2 |
| Sequence | One Letter Code: C
Three Letter Code: Ac-Cys-OH |
| Labeling Target | Glutathione synthetase; Cystine/glutamate transporter |
| Application | Acute and chronic bronchitis, laryngitis, tracheitis or sinusitisPulmonary complications of cystic fibrosisParacetamol overdose
Show alternative translations |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Activity | Stimulator; Activator |
| Areas of Interest | Neurological Disease |
| Functions | Metallopeptidase activity;
Cystine:glutamate antiporter activity |
| Disease | Bronchiectasis; Amyloidosis; Bronchitis; Cystic fibrosis of the lung |
| Source# | Synthetic |
Solubility | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
Format | neat |
Organism | Human |
InChI | InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1 |
InChI Key | PWKSKIMOESPYIA-BYPYZUCNSA-N |
Canonical SMILES | CC(C)C(C)(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13 |
Isomeric SMILES | CC(=O)N[C@@H](CS)C(=O)O |
BoilingPoint | 407.7±40.0 °C at 760 mmHg |
ShelfLife | >2 years if stored properly |
Melting Point | 106-108?°C(lit.) |
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