Adefovir Dipivoxil

Adefovir Dipivoxil is a acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI). It is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.

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CAT#	10-101-107
CAS	142340-99-6
Synonyms/Alias	Adefovir di(pivaloyloxymethyl) ester;Bis(POM)PMEA; GS-0840; Piv2PMEA;9-[2-(Bis[(pivaloyloxy)-methoxy]phosphinylmethoxy)ethyl]adenine
Chemical Name	[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
M.F/Formula	C20H32N5O8P
M.W/Mr.	501.48
Sequence	no
Labeling Target	DNA polymerase/reverse transcriptase
Application	For treatment of hepatitis B and herpes simplex virus infection
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Biological Activity	Adefovir Dipivoxil is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
Areas of Interest	Infection
Functions	Rna-dna hybrid ribonuclease activity
Disease	Chronic type B viral hepatitis
Target	HBV

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Source#	Synthetic
Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
Organism	HBV-D
InChI	InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChI Key	WOZSCQDILHKSGG-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
BoilingPoint	641.0±65.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	98-102ºC