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Cyclosporin A

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CAT#
10-101-77
Synonyms/Alias
Cyclosporine; Ciclosporin; Cyclosporin; Cyclosporin A; Cyclosporine A; Neoral; OL 27-400; Restasis; Sandimmun; Sandimmune
CAS No.
59865-13-3
Sequence
(R-(R*,R*-(E)))-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
M.W/Mr.
1202.61
Molecular Formula
C62H111N11O12
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Cyclosporin A is used for the prophylaxis of graft rejection in organ and tissue transplantation.
Description
Cyclosporin A is a cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It can bind to the cyclophilin and then inhibits calcineurin. Thus, it is widely used in organ transplantation to prevent rejection.
Areas of Interest
Organ transplantation
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