Cyclosporin A is a cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It can bind to the cyclophilin and then inhibits calcineurin. Thus, it is widely used in organ transplantation to prevent rejection.
CAT# | 10-101-77 |
CAS | 59865-13-3 |
Synonyms/Alias | Cyclosporine; Ciclosporin; Cyclosporin; Cyclosporin A; Cyclosporine A; Neoral; OL 27-400; Restasis; Sandimmun; Sandimmune |
Chemical Name | (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
M.F/Formula | C62H111N11O12 |
M.W/Mr. | 1202.61 |
Sequence | (R-(R*,R*-(E)))-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) |
Labeling Target | Peptidyl-prolyl cis-trans isomerase A; Calcium signal-modulating cyclophilin ligand; Calcineurin subunit B type 2; Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
Application | For prevention or treatment of organ (kidney, liver, and heart) transplant and tissue transplant rejection, rheumatoid arthritis, severe psoriasis. |
Appearance | white solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Biological Activity | Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection. |
Areas of Interest | Inflammation/Immunology |
Functions | Calcium ion binding; Virion binding; Peptidyl-prolyl cis-trans isomerase activity |
Disease | Prevention of Cardiac Transplant Rejection; Prevention of Liver Transplant Rejection; Prevention of Kidney Transplant Rejection |
Target | Calcineurin |
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