2-Furoyl-LIGRLO-amide is a potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed, increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation.
CAT# | R1835 |
CAS | 729589-58-6 |
Synonyms/Alias | 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt; 2-fAP; 2-Fly |
M.F/Formula | C36H63N11O8 |
M.W/Mr. | 778 |
Sequence | One Letter Code: LIGRLX (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide) Three Letter Code: Fur-2-oyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 |
Purity | > 95% |
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