CTOP
CTOP is a peptide that acts as a μ-opioid receptor antagonist.
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| CAT# | R1808 |
| Chemical Structure |  |
| CAS | 103429-31-8 |
| Synonyms/Alias | CTOP, (Tyr3,Orn5,Pen7)-Octreotate amide |
| M.F/Formula | C50H67N11O11S2 |
| M.W/Mr. | 1062.26 |
| Sequence | One Letter Code: FCYW{Orn}T{Pen}T-NH2 (Disulfide bridge:Cys2-Pen7)
Three Letter Code: Phe-Cys-Tyr-Trp-{Orn}-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7) |
| Biological Activity | Potent and selective μ opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism. |
| Storage | Desiccate at -20°C |
Solubility | Soluble to 1 mg/ml in water |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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