Pramlintide
Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β-cells of the pancreas along with insulin, after a meal. Like insulin, amylin is completely absent in individuals with Type I diabetes.
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| CAT# | 10-101-28 |
| CAS | 151126-32-8 |
| Synonyms/Alias | AC 0137; AC 137; Symlin; Tripro-Amylin; riproamylin; Pramlintide; LS-181996; LS181996; Amylin |
| M.F/Formula | C171H267N51O53S2 |
| M.W/Mr. | 3949.4 |
| Sequence | Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Disulfide bridge cys2 and cys7) |
| Labeling Target | Amylin receptor |
| Application | Pramlintide (Symlin) has been approved by the FDA as a new injectable drug for diabetes (both type 1 and 2). |
| Activity | Agonist |
| Biological Activity | Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer. |
| Areas of Interest | Metabolic Disease |
| Functions | Receptor activity |
| Disease | Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus |
| Target | Calcitonin receptor |
| Source# | Synthetic |
Long-term Storage Conditions | −20°C |
Organism | Human |
BoilingPoint | N/A |
Melting Point | N/A |
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