Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models.
CAT# | R1840 |
CAS | 106128-89-6 |
Synonyms/Alias | [Succinyl-Asp6, NMePhe8]-Substance P (6-11), |
Chemical Name | N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide |
M.F/Formula | C40H55N7O11S |
M.W/Mr. | 842 |
Sequence | One Letter Code: DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide Three Letter Code: Suc-Asp-Phe-N(Me)Phe-Gly-Leu-Met-NH2 |
Purity | >97% (by HPLC) |
Activity | NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity. |
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