Taltirelin
Taltirelin is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects.
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| CAT# | 10-101-63 |
| CAS | 103300-74-9 |
| Synonyms/Alias | taltirelin hydrate; (1-methyl-4,5-dihydroorotyl)-histidyl-prolinamide; TA-0910; TA 0910; LS-118853 |
| M.F/Formula | C17H23N7O5 |
| M.W/Mr. | 477.46 |
| Sequence | (1-methyl-4,5-dihydroorotyl)- His-Pro-NH2 |
| Labeling Target | Thyrotropin-releasing hormone (TRH) receptors |
| Application | Taltirelin (marketed under the tradename Ceredist) has nootropic, neuroprotective and analgesic effects. |
| Activity | Agonist |
| Biological Activity | Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
| Areas of Interest | Neurological Disease |
| Disease | Spinocerebellar disease |
| Target | Thyroid Hormone Receptor |
| Source# | Synthetic |
Long-term Storage Conditions | −20°C |
InChI | InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1 |
InChI Key | LQZAIAZUDWIVPM-SRVKXCTJSA-N |
Isomeric SMILES | CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N |
BoilingPoint | N/A |
Melting Point | N/A |
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