Z-Leu-Leu-Glu-AMC
An excellent fluorogenic substrate for measuring the peptidylglutamyl-peptide-hydrolyzing (PGPH) activity of the 20S proteasome, which is excited at 340-360 nm and emits at 440-460 nm. It is typically used in cell lysates after experimental treatment.
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| CAT# | R1025 |
| CAS | 348086-66-8 |
| Synonyms/Alias | Proteasome Substrate III, Fluorogenic |
| M.F/Formula | C₃₅H₄₄N₄O₉ |
| M.W/Mr. | 664.76 |
| Sequence | Z-Leu-Leu-Glu-AMC |
| Appearance | Solid lyophilized powder |
| Purity | >95% |
| Source# | Synthetic |
Storage | -20°C |
Solubility | Soluble in DMSO |
InChI | InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1 |
InChI Key | FOYHOBVZPWIGJM-KCHLEUMXSA-N |
Isomeric SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC3=CC=CC=C3 |
BoilingPoint | 967.8±65.0 °C at 760 mmHg |
Melting Point | N/A |
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