Zonisamide

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures, infantile spasm, mixed seizure types of Lennox–Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.

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CAT#10-101-130
CAS68291-97-4
Synonyms/AliasAD-810; CI-912; PD-110843; 1,2-Benzisoxazole-3-methanesulfonamide; 3-(Sulfamoylmethyl)-1,2-benzisoxazole; Benzo[d]isoxazol-3-yl-methanesulfonamide
M.F/FormulaC8H8N2O3S
M.W/Mr.212.23
Labeling TargetCarbonic anhydrase;
Voltage-dependent T-type calcium channel;
Sodium channel protein type 1 subunit alpha
ApplicationZonisamide has been used in the treatment in Epilepsy & Parkinson's disease & Tardive dyskinesia & Obesity & Migraines & Bipolar depression.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityInhibitor
Biological ActivityZonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity.
Areas of InterestCardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
FunctionsVasopressin receptor activity
TargetCarbonic Anhydrase
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