Nutritional Effects
Most of the previous baby formulas don’t contain nucleotides and sometimes the formulas could have atopic and allergic reactions; that’s why their ability to fight infection is weak. Breast milk is the best nutrition for infants, because it contains a large amount of nucleotides so that people prefer to manufacture the infant nutrition according to the nutrients in breast milk. Exogenous nucleotides in milk substitutes may be beneficial for newborn infants in particular, enabling to maintain the body’s immune system, promote intestinal maturation, and develop lipid metabolism in the liver. Clearly, necleotides have played an important role.

Immune Ability
Many researchers believe that nucleotides are crucial for maintaining the body’s normal immune function, which could help enhance the baby’s immunity and resistance to infection. US pediatricians Pickering and other colleagues conducted a year-long clinical comparative study on 311 babies. The study showed that fed babies with breast milk ( an equal amount of nucleotides ) could own a higher antibody immune response to e-influenza vaccine. Breastfed babies have a stronger immunity than formula-fed ones ( without adding nucleotides ). In addition, diphtheria antibody concentrations are also significantly higher than the untreated groups, which means adding nucleotides to infant formula can be helpful to enhance H influenza and oral poliovirus (OPV) antibody response.

Liver Function
Resynthesis nucleotides are mainly performed in the liver and they require a lot of energy. The nucleotide pathway is to form a new nucleotide using fragments or exogenous nucleotides, thus requiring less energy. Although the liver has the ability to complete the de novo synthesis of nucleotides, once the body has an immune stress it could result in activation and proliferation of the T lymphocyte. Besides, it will cause a rapid increase in the synthesis of nucleotides, which indicates a fact that material requirements involved in energy metabolism also get increased, so exogenous polynucleotide is quite necessary.

Actually, on the other hand, safety issues for nucleotides’ application could be payed more attention. Taking promoting metabolism as an example, exogenous polynucleotide may be helpful to those newborn’s lipoprotein. Truly, enhancing the physical immunity under proper ways is always the most important.