Non-competitive nicotinic cholinergic antagonist that selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). It blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release, and also stimulates mast cell release of histamine via a separate mechanism.
CAT# | R1008 |
CAS | 142211-96-9 |
Synonyms/Alias | Chromogranin A344-364 |
M.F/Formula | C107H173N37O26S |
M.W/Mr. | 2425.84 |
Sequence | RSMRLSFRARGYGFRGPGLQL |
Labeling Target | Nicotinic receptor |
Appearance | White lyophilised solid |
Purity | >98% |
Activity | Antagonist |
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