Selective antagonist of vasopressin V1A receptor that inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
CAT# | R1081 |
CAS | 73168-24-8 |
Synonyms/Alias | Manning Compound, [Pmp1, Tyr(OMe)2, Arg8] Vasopressin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 trifluoroacetate salt (Disulfide bond) |
M.F/Formula | C52H74N14O12S2 |
M.W/Mr. | 1151.38 |
Sequence | YFQNCPRG(Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide) |
Labeling Target | Vasopressin Receptor |
Appearance | White lyophilised solid |
Purity | >98% |
Activity | Antagonist |
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