Intermedins

* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

Online Inquiry

CAT# Product Name M.W Molecular Formula Inquiry
I04001 Intermedin (rat) 5216.95 C226H361N75O64S2 Inquiry
I04002 Intermedin (human) 5100.80 C219H349N69O66S3 Inquiry
I04003 Biotinyl-Intermedin (rat) 5443.25 Inquiry
I04004 Intermedin (human) trifluoroacetate salt 5100.8 C₂₁₉H₃₄₉N₆₉O₆₆S₃ Inquiry
I04005 Intermedin (rat) trifluoroacetate salt 5216.95 C₂₂₆H₃₆₁N₇₅O₆₄S₂ Inquiry
I04006 Intermedin-53 (human) trifluoroacetate salt 5791.49 C24H39N83O73S3 Inquiry

Introduction

Intermedin (IMD), is a new type of cardiovascular regulatory peptide found in recent years. It is a new member of calciton gene related peptide (CGRP) also including calcitonin (CT), adrenomedullin (ADM), α-CGRP, β-CGRP and amylin. The gene and protein structure of IMD are the same as those of amino acid sequence, nucleotide sequences, and biological activities of ADM-2 discovered in the mammal, and they are be sure the same substance. Multiple protease cleavage sites are distributed on the IMD precursor consists of 148 amino acid residues, which are cleaved in vivo to IMD1-47 containing 47 amino acids, IMD8-47 containing 40 amino acids, and active fragment of IMD1-53.

Mechanism of IMD

IMD works through the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) receptor complex (CRLR-RAMP), in which the CRLR is a G protein coupled receptor and is not a specific receptor protein of CGRP family and it only has receptor function when it binds to RAMPs. As we all know, RAMPs have three subtypes including RAMP1, RAMP2 and RAMP3, and IMD has a unique receptor binding property of combining with CRLR/RAMPs1-3. In addition to the CRLR/RAMPs system, IMD may also bind to CGRP receptors to exert its biological effects. Besides, IMD can activate the cyclic adenosine monophosphate (cAMP) signaling pathway, which is an important pathway for biological effects, and can participate in myocardial contraction, vasodilation and regulate biological effects such as cell proliferation, hypertrophy, migration, and apoptosis. Furthermore, ADM has a strong ability to promote NO synthesis, and the NO mediates its effects on vasodilation, inhibition of cell proliferation, differentiation and anti-apoptosis, and plays an important role in the occurrence and development of cardiovascular diseases and the maintenance of vascular homeostasis. Since IMD is similar to ADM and is endothelium dependent, it is speculated that IMD also has the effect of upregulating NO, and at the same time, it was confirmed that IMD1-53 mainly increased the synthesis of NO and the activity of nitric oxide synthase (NOS) in rat aorta by increasing the activity of endothelial NOS (eNOS), and the effect was stronger than that of ADM.

Application of IMD

Owing to the special features of IMD, it is widely distributed and plays important roles in many tissues, especially in the cardiovascular system, which is involved in regulating blood pressure, promoting angiogenesis, protecting endothelial barrier function, and the pathogenesis of many diseases, such as arteriosclerosis, hypertension and vascular calcification. Therefore, IMD has become a promising target for the treatment of cardiovascular disease.

References

  1. Holmes, D., Campbell, M., Harbinson, M., & Bell, D. (2013). Protective effects of intermedin on cardiovascular, pulmonary and renal diseases: comparison with adrenomedullin and CGRP. Current Protein & Peptide Science, 14(4), 294-329.
  2. Bell, D., & Mcdermott, B. J. (2010). Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems. British Journal of Pharmacology, 153(S1), S247-S262.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Customer Support & Price Inquiry

Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!

 Acid-sensitive ion channels (ASICs) are a class of proton-gated ion channels belonging to the Degenerin/Epitheli ...

 Dynorphin A (1-13) [Dyn-A (1-13)] is a short-chain polypeptide containing 13 amino acids and having extensive bi ...

  BIM 189 is one of the most potent bombesin antagonists known in the guinea pig and 3T3 cell systems but has 40% ...

The voltage-gated Kv1.3 channel in effector memory T cells serves as a new therapeutic target for multiple scler ...

 Kassinin, a new peptide of amphibian origin, has been traced in the skin of the African frog Kassina senegalensi ...

Quick Inquiry
×
Contact Us

USA

Address:

Tel: |

Email:

Germany

Address:

Copyright © 2024 Creative Peptides. All rights reserved.