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With the increasing proportion of cancer in the world year by year, cancer has become the main cause of death and a major public health problem in the world. Anticancer peptides can destroy the structure of tumor cell membrane or inhibit the proliferation and migration of cancer cells and the formation of tumor blood vessels, almost no hemolysis and no damage to normal human cells, which has become a hot spot in the research of new anti-tumor drugs. Because of the need to constantly find new therapeutic drugs, especially those that can escape drug resistance, inhibit metastasis and have no other important side effects, anticancer peptides have become one of the goals of new research. Anticancer peptides are a new type of anticancer drugs with small molecular peptides, which kill cancer cells by destroying the structure of tumor cell membrane or inhibiting the proliferation and migration of cancer cells and the formation of tumor blood vessels, but have low toxicity to normal cells. It is a hot spot in the research of new anti-tumor drugs at present.
Cancer kills millions of people every year. As a traditional means of cancer treatment, chemotherapy has some defects, such as low selectivity, great side effects, and multi-drug resistance and so on. Compared with traditional chemotherapeutic drugs, peptides as anti-cancer compounds have high selectivity and low toxicity. The modification of anticancer peptides and the combination of anticancer peptides with traditional drugs can give better play to the effect of anticancer peptides, which will become an important direction of the development of anticancer peptides.
References
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Overview of the kinin system Kinins are peptide hormones that are formed as part of the kinin-kallikrein system (KKS). kinin ...
Teicoplanin is a glycopeptide antibiotic developed after vancomycin for the treatment of Gram-positive (G+) cocc ...
Aprotinin is a natural proteinase inhibitor polypeptide derived from bovine lung tissue. It is a monomeric glo ...
Glucagon is a 29-amino acid peptide hormone that is synthesized in pancreatic α cells from the proglucagon precursor by proho ...
The peptide neuroprotectant Tat-NR2B9c, also known as NA-1, is a Tat peptide consisting of the nine C-terminal ...