Custom Peptide Synthesis

cGMP Peptide SynthesisCyclic and Stapled Peptide SynthesisCell-penetrating Peptide ConjugationLarge-scale Peptide Production

At Creative Peptides, we specialize in providing high-quality, custom peptide synthesis services tailored to your research, pharmaceutical, and industrial needs. Whether you're exploring new drug targets or developing next-generation biomaterials, we deliver reliable, scalable peptide solutions - with precision, speed, and cost-efficiency.

Peptide Synthesis Methods

Our custom peptide synthesis services range from research grade to many API peptides. Creative Peptides is proficient in different synthesis methods to meet different needs.

  • Liquid Phase Peptide Synthesis is used for the synthesis of short peptides (such as dipeptides).
  • Solid Phase Peptide Synthesis is used to prepare biologically active peptides including long, difficult, and hydrophobic peptides.
  • Biosynthesis provides many peptide modifications and customized peptides for diagnostic and therapeutic applications.

Peptide Synthesis Services

High-Quality Peptide Synthesis

We provide high-quality custom peptide synthesis with a focus on purity, yield, and accuracy. Our peptide synthesis service supports all lengths, sequences, and modifications. Whether you need simple peptides or complex peptides, we guarantee a service that meets your exact specifications.

Our team specializes in a variety of peptide modifications, including: Phosphorylation, Acetylation, Cyclization, PEGylation, Fluorescent labeling and Biotinylation. These modifications are perfect for your research or therapeutic applications.

After synthesis, we offer peptide purification services using HPLC and SPE techniques to ensure that your peptide is of the highest purity. We offer custom purification based on the specific needs of your peptide.

Peptide Characterization and Quality Control

We conduct rigorous quality control for each batch of peptides synthesized. Our peptide characterization services include: Mass spectrometry (MS), HPLC analysis, Amino acid analysis and Structural validation.

From small-scale peptides for research to large-scale production for commercial purposes, we handle projects of any size. We ensure scalable production that meets both your budget and timeline.

We provide custom peptides for scientific research, including: Antigen peptides, Immunological peptides, Antibody production, Protein-protein interaction studies and Drug discovery. Our peptides are designed to support biotech research, pharmaceutical development, and diagnostic applications.

Peptide Synthesis for Therapeutic

Our peptide synthesis services support therapeutic applications, such as: Vaccine development, Targeted drug delivery and Hormonal therapy peptides. We use the highest standards to ensure that peptides used in therapeutic applications meet regulatory requirements.

Peptide Synthesis for Diagnostic Tools

We offer custom peptides for use in diagnostic kits, including peptides for enzyme-linked immunosorbent assays (ELISA), immunohistochemistry (IHC), and western blotting.

Peptide Libraries and Combinatorial Peptide Synthesis

We provide peptide libraries for screening and drug discovery purposes. Whether you're looking for random libraries or focused libraries with specific sequences, we offer customizable solutions.

Detailed Peptide Synthesis Services

We can synthesize peptides of 200 amino acids and above. Longer peptides can be prepared by recombinant peptide technology.

Lipopeptides Synthesis Service

We offer custom lipopeptide synthesis for vaccine adjuvants, antimicrobial peptide research, and delivery system applications. Our services support lipidation at N-terminal or side chains with flexible chain lengths and formats.

Recombinant Peptide Synthesis

We produce recombinant peptides via E. coli or yeast expression systems, suitable for complex, post-translationally modified peptides. Our services include gene synthesis, expression optimization, and protein purification.

Peptoid Synthesis

Our custom peptoid synthesis service provides sequence-defined N-substituted glycine oligomers, ideal for protease-resistant biomaterials, therapeutic leads, and bioactive surface coatings.

Glycopeptides Synthesis

We specialize in glycopeptide synthesis, incorporating natural or custom-designed carbohydrate moieties to mimic glycosylation patterns. Applications include vaccine development, immune profiling, and structural biology.

Oligopeptide Synthesis

We provide reliable oligopeptide synthesis (2-20 amino acids) with high purity and optional labeling or modifications. Suitable for basic research, assay development, and diagnostic applications.

Cyclic Peptides Synthesis

We specialize in custom cyclic peptide synthesis, offering high-quality, stable, and bioactive peptides with enhanced affinity, stability, and protease resistance. Ideal for drug discovery, protein-protein interaction studies, and targeted therapy, our expertise ensures efficient ring closure and scalable production, including disulfide or lactam bridge formations.

Bicyclic Peptides Synthesis

Our bicyclic peptide synthesis enables development of ultra-stable peptide scaffolds with enhanced binding affinity and protease resistance. Ideal for therapeutic targeting and molecular probes.

Custom MHC-Peptide Tetramer Synthesis

We provide high-affinity MHC-peptide tetramer synthesis for accurate T-cell epitope identification and immune monitoring. Our custom solutions ensure high purity and precise MHC class I or II loading to match your immunology research needs.

Peptide Nucleic Acid (PNA) Synthesis

Our custom PNA synthesis service offers synthetic DNA analogs with superior hybridization stability and resistance to enzymatic degradation, ideal for antisense therapies, diagnostics, and molecular probes.

Stapled Peptide Synthesis

We specialize in the synthesis of stapled peptides with hydrocarbon bridges to enhance α-helicity, protease resistance, and cellular uptake-ideal for targeting intracellular protein-protein interactions.

Long Peptides Synthesis

Our advanced synthesis platforms support long peptide production (up to 100+ amino acids) with high yield and purity. We excel in difficult sequences and post-synthesis modifications, including segment ligation and C-terminal amidation.

Large-Scale Peptide Synthesis

From milligrams to grams, our large-scale peptide synthesis services ensure consistent quality, batch reproducibility, and regulatory documentation-ideal for preclinical development and commercial applications.

Special Antigen Peptides Services

We design and produce custom antigenic peptides tailored for antibody generation, epitope validation, and vaccine projects. Special formats like phosphorylated, glycosylated, or neoantigen peptides are fully supported.

Peptide Library / Array Synthesis

We offer high-throughput peptide library and array synthesis, enabling systematic screening of epitope specificity, binding affinity, and structure-activity relationships. Ideal for drug discovery, vaccine development, and biomarker research.

Custom Locked Nucleic Acid (LNA) Synthesis

We provide precise LNA synthesis for nucleic acid therapeutics and diagnostics. LNAs offer unmatched hybridization affinity and nuclease resistance, with scalable, customizable production and strict quality control.

Custom Bridged Nucleic Acid (BNA) Synthesis

Our BNA synthesis service delivers modified oligonucleotides with locked conformations, ensuring high thermal stability and affinity for diagnostics and gene regulation studies.

Multiple Antigenic Peptides (MAPs) and Dendrimers

We synthesize MAPs and dendrimeric peptide structures to boost immunogenicity without carrier proteins. Custom branching, linker design, and multivalency options available.

D-Amino Acid Peptide Synthesis

Our team synthesizes D-amino acid-containing peptides to enhance protease resistance and bioavailability. Custom mirror-image peptides are available for stability testing, therapeutic development, or structural studies.

Click Chemistry Peptides

We offer click chemistry-compatible peptides with azide or alkyne groups for rapid, site-specific conjugation. Suitable for bioconjugation, surface immobilization, and probe development.

Custom Peptide Inhibitor Synthesis

We design and synthesize custom peptide inhibitors targeting enzymes, receptors, or protein-protein interactions. Our chemists optimize stability, specificity, and cell permeability to support preclinical research and screening.

Peptide Synthesis Quality Control

After peptide synthesis, each peptide is routinely analyzed by LC-MS, MALDI-MS, or HPLC to confirm the identity and quality of the customized peptide.

  • MALDI-MS

All peptides are analyzed by MALDI-MS to determine the molecular weight of the synthesized peptides.

  • HPLC

MALDI is an excellent method to determine the presence of the desired product, but it is not sufficient to determine purity. So, all non-crude peptides must be analyzed by reverse-phase HPLC (RP-HPLC) to determine purity. Other QC analysis, such as amino acid analysis, NMR, CE, and peptide content determination can be performed to confirm the quality of customized peptides.

  • Extended quality control (optional)

Chromatography (HPLC, TLC, GC, IC)
Chromatography combined with mass spectrometry (LC-MS / ESI)
Spectroscopy (UV-Vis, IR, NMR)
Metal analysis (AAS, ICP, ICP-MS)
Elemental analysis
Titration (acid-base titration, Karl Fischer titration)
Amino acid analysis
Peptide sequencing

Why Choose Our Custom Peptide Synthesis Services?

  • Expertise

    With years of experience in peptide synthesis and modification, we deliver top-tier peptides.

  • Precision

    We ensure accurate sequence design and synthesis that meets your exact specifications.

  • Flexibility

    Whether you're synthesizing small peptides or large proteins, our services are fully scalable.

  • Quality control

    All peptides are analyzed by MS and HPLC

  • Unlimited

    Short or long peptides, chemical or recombinant peptide technology

  • Competitive Pricing

    High-quality peptides at affordable rates with no compromise on quality.

  • Confidentiality

    We prioritize client confidentiality and secure handling of intellectual property.

  • Diversity

    Large number of conjugations, modifications, and labeling

Custom Peptide Synthesis Workflow

Application Fields of Custom Peptides

Biomedical Research

  • Protein-protein interaction studies
  • Cell signaling pathway exploration
  • Receptor binding assays
  • Immunogenic epitope mapping

Therapeutic Development

  • Peptide-based drug discovery
  • Vaccine design (e.g., neoantigen peptides)
  • Antimicrobial/anticancer peptide screening
  • Targeted drug delivery platforms

Diagnostics & Assays

  • Peptide-based ELISA kits
  • Biosensor development
  • Peptide microarrays for screening
  • Antibody generation and validation

Cosmetics & Dermatology

  • Anti-aging peptide actives
  • Collagen-boosting formulations
  • Skin barrier peptides

Agricultural & Veterinary Research

  • Peptide hormones for livestock
  • Pathogen-specific epitope peptides
  • Insecticidal/antiviral peptide agents

FAQ

1. What is custom peptide synthesis?

2. Can I modify my peptide during synthesis?

3. What is the minimum peptide length you can synthesize?

4. How do I place an order for custom peptide synthesis?

5. Can I get a peptide library synthesized?

Other Services You May Need

Peptide Modifications & Labels

Creative Peptides also has extensive experience in the design and production of modified peptides. We provide a variety of peptide modifications, labeling, and bioconjugation with other biomolecules, including

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