Cyclic Peptides Synthesis

Targeted Drug Delivery Peptide Therapeutics Development Cell-penetrating Peptide Conjugation Advanced Cyclization Techniques

Creative Peptides provides a wide range of cyclic peptide synthesis, which play a key role in different processes and have good therapeutic potential because they have several favorable properties, such as displaying a large surface area, which leads to high affinity and selectivity for protein targets, as well as their limited conformational flexibility, reducing entropy penalties during binding, thus improving their binding performance.

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Cyclic Peptides Synthesis Methods

Depending on the cyclization position, there are several methods to synthesize cyclic peptides: head-to-tail, side-chain-to-side-chain, head-to-side-chain, and side-chain-to-tail, head-to-backbone, backbone-to-tail, side-chain-to-backbone, backbone-to-side-chain. (see figure below). While head-to-tail cycles are usually formed by amide bond formation, side-chain-to-side-chain cycles are most often synthesized via Cys-Cys or amide bond formation.

Cyclic Peptides

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Backbone Cyclization
Backbone cyclic peptides are easily assembled via the formation of an amide bond between the peptides own N-terminus amine and C-terminus carboxylic acid. Our commonly used methods are chemical synthesis and biosynthesis. Creative Peptides perform the reaction with very high yields, and routinely provide over 98% purified cycled peptides.
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Side-chain Cyclization
Side chain-to-side chain cyclization is frequently employed to stabilize and select specific conformations and to reduce susceptibility toward proteolytic degradation. Creative Peptides have the capable to selectively protect, and then deprotect peptide sidechains to allow for the formation of lactam bridges between Lysine or Diaminopropanoic acid, and Glutamic and Aspartic Acids. Creative Peptides can even perform multiple different sites for bridge formation.
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Disulfide-rich Peptides
Disulfide bonds are widely present in hormones, enzymes, and immunoglobulins, and are thought to play an important role in reconstructing the conformation of biologically active peptides. To further enhance biological activity, people often introduce disulfide bonds to modify bioactive peptides. Creative Peptides usually add two cysteine residues to the peptide sequence, and the dilute solution of the peptide undergoes mild oxidation to form the desired intramolecular disulfide bond between the two cysteine residues. Ugi reaction also can be provided.
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Hydrocarbon-Stapled Peptide
Disulfide bonds can be easily reduced to their acyclic mercaptan form in the intracellular environment. This challenge can be overcome by hydrocarbon-bound peptide synthesis, which can form a stable α-helix structure. It can mimic the typical molecular structure at the protein-protein interaction interface. When locked in this stable configuration, the constrained peptides can penetrate the cell and act on the protein targets in the cell.

Cyclic Peptides Synthesis Services

Custom Cyclic Peptide Synthesis

We offer custom cyclic peptide synthesis for a variety of applications, from basic research to complex therapeutic peptides. Our team ensures high purity, efficiency, and flexibility in the synthesis process, enabling the production of peptides that meet your precise specifications.

Full-Length Cyclic Peptides
Small and Large Peptides
Tailored Modifications and Conjugations

High-Throughput Cyclic Peptide Synthesis

Accelerate your research with our high-throughput cyclic peptide synthesis services. We employ automated systems to produce large quantities of peptides quickly and efficiently, making it ideal for screening campaigns and large-scale projects.

Fast Turnaround Times
Automation for Scalability
ARobust Quality Control

Peptide Cyclization Techniques

Our peptide cyclization techniques include a range of methods for efficient ring formation, ensuring that the cyclic peptides are stable and functional. We use both chemical and enzymatic cyclization strategies to produce peptides with diverse ring structures.

Head-to-Tail Cyclization
Disulfide Bond Formation
Stapled Peptides

Peptide Modification and Labeling

Enhance your cyclic peptides with various modifications such as fluorescent labeling, biotinylation, and PEGylation for improved bioavailability, stability, and detection. Our modification services are ideal for peptide-based assays and diagnostic applications

Fluorescent Tags
Biotinylation
PEGylation for Enhanced Solubility

Peptide Library Construction

We provide cyclic peptide library construction services to help you explore diverse peptide sequences. These libraries are invaluable for drug discovery, biomarker identification, and functional screening.

Diverse Sequence Variations
High-Density Libraries
Screening for Target Interaction

Peptide Purification & Characterization

We use advanced techniques to purify and characterize your cyclic peptides to ensure they meet the highest standards. Our services include HPLC purification, mass spectrometry, and NMR analysis to confirm peptide identity, purity, and structure.

HPLC Purification
Mass Spectrometry
NMR Structural Analysis

Peptide Therapeutics Development

Explore the therapeutic potential of cyclic peptides with our specialized services for drug development. From initial synthesis to preclinical studies, we assist in developing peptide-based therapeutics for cancer, autoimmune diseases, neurodegenerative diseases, and more.

Targeted Drug Delivery
Anticancer Peptides
Antimicrobial Cyclic Peptides

Contract Research and Collaboration

Partner with us for contract research and collaborative projects. Whether you're a biotech company, pharmaceutical firm, or academic institution, we offer comprehensive support for your cyclic peptide research needs.

Flexible Collaboration Models
Confidentiality Assured
Custom Research Solutions

TAT Peptide Synthesis

We specialize in TAT peptide synthesis, offering high-quality peptides for drug delivery, gene therapy, and targeted cellular interactions. Our expertise ensures efficient and reliable synthesis with optimal purity and bioactivity, ideal for your research and therapeutic applications.

DOTAGA Chelating Peptide Synthesis

Our DOTAGA chelating peptide synthesis service provides custom peptides with DOTAGA (1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid) for use in radiolabeling and molecular imaging. With precise synthesis techniques, we ensure high-quality peptides for applications in diagnostic imaging and targeted therapies.

Synthesis of Head-to-Tail Cyclic Peptides

We offer head-to-tail cyclic peptide synthesis, a method that forms stable cyclic peptides through reliable chemical or enzymatic cyclization techniques. Our service ensures robust peptide structures with enhanced stability, ideal for drug discovery and biomolecular research.

Bicyclic Peptides Synthesis

Our bicyclic peptides synthesis service delivers peptides with two interconnected rings, enhancing stability and bioactivity. By utilizing advanced cyclization techniques, we provide highly potent peptides suitable for therapeutic, diagnostic, and bioengineering applications.

Key Technologies and Platforms for Cyclic Peptides Synthesis

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Solid-Phase Peptide Synthesis (SPPS)

We use solid-phase peptide synthesis (SPPS), a widely recognized technique that allows for the efficient assembly of cyclic peptides, ensuring high purity and high yields throughout the synthesis process.

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High-Performance Liquid Chromatography (HPLC)

To ensure the highest peptide purity, we employ HPLC for precise peptide purification, removing any impurities and ensuring that the final product meets your exact specifications.

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Mass Spectrometry (MS)

We utilize mass spectrometry (MS) to accurately confirm the molecular weight and structure of the synthesized cyclic peptides, providing essential data for quality control and verification.

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Nuclear Magnetic Resonance (NMR) Spectroscopy

Our NMR spectroscopy platform allows us to verify the structural integrity of cyclic peptides, ensuring that each molecule maintains its intended conformation for optimal performance in your applications.

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Automated Peptide Synthesizers

For high-throughput peptide synthesis, we rely on automated peptide synthesizers, which streamline the production of large quantities of peptides with consistent quality and minimal turnaround time.

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Peptide Modification Platforms

Our peptide modification platforms enable the efficient addition of functional groups, such as fluorescent labels, biotinylation, and PEGylation, enhancing the peptide's bioavailability, stability, and targeting ability.

Why Choose Us for Cyclic Peptide Synthesis?

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Experienced Peptide Synthesis Experts
Our team of specialists brings years of expertise in cyclic peptide synthesis, ensuring high-quality results.
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State-of-the-art Facilities and Equipment
We utilize the latest technology and equipment to deliver precise and reliable peptide synthesis.
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Competitive Pricing
We offer cost-effective solutions without compromising on quality, making our services accessible for all project sizes.
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Exceptional Quality Control and Testing
Every peptide we synthesize undergoes rigorous testing to guarantee purity and functionality.
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Global Client Base with Proven Results
We have successfully delivered custom cyclic peptides to clients worldwide, ensuring high customer satisfaction and trust.
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Scalability
From small-scale to high-throughput peptide synthesis, we provide flexible solutions for any project size.

Cyclic Peptides Synthesis Workflow

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Initial Consultation
We begin with a detailed consultation to understand your specific needs, including peptide sequence, modifications, and application requirements.
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Custom Peptide Design
Our experts work with you to design a custom cyclic peptide that fits your research goals, ensuring the peptide sequence and cyclization method are optimized for stability and bioactivity.
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Peptide Synthesis
Using solid-phase peptide synthesis (SPPS), we efficiently assemble your cyclic peptide, ensuring high purity and yield throughout the process.
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Peptide Purification & QC
We employ HPLC purification and mass spectrometry (MS) to thoroughly purify and confirm the identity and structure of your cyclic peptide, ensuring it meets the highest quality standards.
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Peptide Modification (if needed)
If necessary, we add functional groups such as fluorescent labeling, biotinylation, or PEGylation to enhance the peptide's functionality for applications like drug delivery or diagnostics.
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Delivery & Support
Once your peptide is synthesized, purified, and modified, we provide fast delivery and ongoing support, ensuring it meets your research or development timelines.

Application Fields of Cyclic Peptides

Drug Discovery and Development

Cyclic peptides have emerged as valuable tools in drug discovery, offering unique properties such as enhanced stability and target specificity. Our cyclic peptide synthesis services help researchers create potent peptide-based drugs, enabling better targeting of diseases like cancer, infections, and autoimmune disorders. By utilizing advanced cyclization techniques, we can develop peptides with improved pharmacokinetics and therapeutic efficacy, which are crucial for the creation of next-generation therapeutics.

Cancer Therapy

Cyclic peptides play a pivotal role in cancer therapy by targeting specific tumor markers and cancer cells with high precision. Our synthesis services focus on creating cancer-targeting cyclic peptides that are able to bind to tumor receptors with high affinity. These peptides are being increasingly used in the development of anticancer drugs and immunotherapies, improving the specificity and reducing side effects compared to conventional therapies.

Diagnostic Imaging

In the field of molecular imaging, cyclic peptides are often used as targeting agents for diagnostic applications, such as PET (Positron Emission Tomography) and MRI. Our DOTAGA chelating peptide synthesis service ensures the synthesis of peptides that can be radiolabeled, allowing for precise imaging of tissues and organs. These peptides enable researchers and clinicians to monitor disease progression, identify abnormalities, and improve the accuracy of early diagnoses.

Vaccine Development

Cyclic peptides have shown great promise in vaccine development, particularly for peptide-based vaccines targeting specific pathogens or diseases. By synthesizing immunogenic cyclic peptides, we help researchers create vaccines with high stability and immunogenicity. These vaccines are not only more stable at room temperature but also capable of triggering stronger and longer-lasting immune responses.

Drug Delivery Systems

One of the significant advantages of cyclic peptides is their ability to enhance drug delivery systems. Due to their stability and ability to penetrate cell membranes, cyclic peptides are increasingly used as carriers for delivering drugs, proteins, and genes directly to target cells. Our synthesis services can provide TAT peptides and other delivery peptides for targeted therapy, improving the efficiency and reducing side effects of treatments.

Antimicrobial Peptides

Cyclic peptides are also being explored as alternatives to traditional antibiotics in the fight against drug-resistant bacteria and infections. Our antimicrobial cyclic peptide synthesis services focus on creating peptides with strong antimicrobial properties that are effective against a broad range of pathogens. These peptides can be used in the development of antibiotic therapies that overcome the growing threat of antimicrobial resistance.

Biomolecular Research

Cyclic peptides are widely used in biomolecular research to study protein-protein interactions, enzyme activity, and cellular signaling pathways. Our cyclic peptide synthesis services offer high-quality peptides that can be used as tools for research on gene expression, protein binding, and signal transduction, enabling scientists to explore complex biological systems in greater detail.

FAQs

1. What is cyclic peptide synthesis?

2.Why should I use cyclic peptides in my research?

3. Can you customize cyclic peptides for specific applications?

4.How do you ensure the quality of your cyclic peptides?

5.Can you help with large-scale peptide synthesis?

Explore Our Product Range

CAT#	Product Name	M.W	Molecular Formula	Get a Quote
10-101-103	Vancomycin	1449.25	C66H75Cl2N9O24	Inquiry
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R1824	Cyclo(RGDyK)	847.7	C31H43F6N9O12	Inquiry
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R2239	Oritavancin	1793.1	C86H97Cl3N10O26	Inquiry
R2240	Bacitracin	1422.69	C66H103N17O16S	Inquiry
R2241	Viomycin	685.69	C25H43N13O10	Inquiry
R2242	Colistin	1169.5	C53H100N16O13 (for E1)	Inquiry
R2243	Micafungin	1270.27	C56H71N9O23S	Inquiry
R2244	Anidulafungin	1140.24	C58H73N7O17	Inquiry
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R2246	Paritaprevir	765.88	C40H43N7O7S	Inquiry
R2247	Grazoprevir	766.9	C38H50N6O9S	Inquiry
Z10-101-154	Daptomycin	1620.69	C72H101N17O26	Inquiry
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