| Services | Description |
|---|
| Peptide N-Terminal Modification | Peptides can be modified at the N terminus. In general, some standard peptide moieties must be accessible
in order to be modified: an N-terminal amino group, the amino group of Lys, the thiol group of Cys, the
hydroxyl groups of Ser, Thr, and Tyr. These modifications might increase the biological activity of a
peptide and prevent degradation by enzymes. |
| Peptide C-Terminal Modification | The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the
C-terminal COOH. This modification is added to prevent enzyme degradation, to mimic native proteins, and
in some cases to remove hydrogen bonding at the C-terminal of the peptides which may interfere with the
assays. |
| Unusual & Non-natural Amino
Acids Modification | The introduction of non-natural amino acids generates modifications in the secondary and tertiary
structures of a peptide, and is used to further enhance the stability and activity of peptide sequences. |
| Peptide PEGylation | For PEG peptides, the PEG is usually attached to the peptide using standard amide bond formation but other
linkage chemistry is possible as well (e.g. thiol-maleimide, oxime ligation, click chemistry). PEGylating
your peptide may overcome many of the challenges for peptide drug candidates. |
| Fluorescent Dye/FRET Pairs
Modification | Fluorescence and dye labeled peptides have been developed for in vivo biomedical imaging, protein
binding and localization studies. The large number of commercially available fluorophores, many of them in
the form of activated species ready for derivatization, has simplified the synthetic effort required to
obtain the modified peptides and increased the flexibility of the designs. |
| Post-translational Modification | Protein post-translational modifications (PTMs) are important in the study of biology and disease
prevention and treatment, which can increase the functional diversity of the proteome by the covalent
addition of functional groups or proteins, proteolytic cleavage of regulatory subunits, or degradation of
entire proteins. |
| Cyclic Peptides | Disulfide-rich cyclic peptides and their disulfide bonds often have exciting potential as leads or
frameworks in drug discovery. It can improve the potency, rigidity, target selectivity, and stability of
proteases and stabilize the secondary structure of peptides. |
| Custom Labeling | We can create the best custom labels for all your needs just about any custom labeling system that your
operation requires. Throughout the years, Creative Peptides has created many custom solutions that have
become a standard in our industry |
| Custom Conjugation Service | Peptides are often not sufficiently immunogenic to elicit an immune response alone. Synthetic peptides
(1,000–3,000 Da), which are widely used to generate antibodies that can be made immunogenic by conjugation
to a suitable carrier. |
| Peptide Tags | Protein and peptide (epitope) tags are widely used in protein purification and protein detection. Protein
tags refer to those with more than a dozen of amino acids, for example, green fluorescent protein; peptide
tags and epitope tags are used interchangeably, referring to the likes of FLAG, Myc epitope, and
poly-histidine. |
| Biotinylated Peptides | Biotinylated peptides are very useful in immunoassay studies, such as attaching peptides to avidin-coated
microtitration plates. In the solid-phase synthesis of Fmoc, biotin can be connected to the N-terminal of
the peptide or to the side chain of lysine (Lys) or glutamate (Glu). |
| Peptide Dimers | Peptide dimer is a polymer complex formed by two peptide monomers or a single peptide (usually
non-covalently bound). Peptide dimers or polymers have many advantages over their monomer counterparts.
For example it is known that the dimerization of GPCR ligands can lead to a significant increase in
affinity. |
| PNA Backbone Modification | Peptide nucleic acid (PNA) is an artificial oligonucleotide mimetic with a peptidic backbone in lieu of a
phosphoribosyl backbone. As such, it combines the properties of both peptides and nucleic acids. |
| PNA Nucleobase Modification | Peptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide
backbone, as well as an N-terminus and a C-terminus. |
