Potent and selective amylin receptor antagonist that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Through attenuating the activation of initiator and effector caspases in vitro, it blocks amyloid β-induced neurotoxicity. It can increase glucagon secretion, accelerate gastric emptying, change plasma glucose levels and increase food intake in vivo.
CAT# | R0952 |
CAS | 151804-77-2 |
M.F/Formula | C127H205N37O40 |
M.W/Mr. | 2890.25 |
Sequence | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
Labeling Target | Amylin receptor |
Application | Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. |
Appearance | White lyophilised solid |
Purity | >98% |
Activity | Antagonist |
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