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APIs

Goserelin Acetate

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CAT#
10-101-20
Synonyms/Alias
(D-Ser(tBu)6; Azagly10)-LHRH; goserelin; Zoladex; Decapeptide I; Goserelin acetate; Gosereline; Goserelinum; Goserelina; Goserelin; ICI 118630; ICI-118630; ICI118630
CAS No.
145781-92-6
Sequence
Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 acetate salt
M.W/Mr.
1269.43
Molecular Formula
C59H84N18O14
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Goserelin acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Description
Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
Areas of Interest
Cancer Research, Pituitary & Hypothalamic Hormones, Veterinary Medicine
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