Icatibant
Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role.
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| CAT# | 10-101-163 |
| CAS | 130308-48-4 |
| Synonyms/Alias | HOE 140 |
| M.F/Formula | C59H89N19O13S |
| M.W/Mr. | 1304.52 |
| Sequence | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg |
| Labeling Target | B2 bradykinin receptor |
| Application | Approved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections. |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Activity | Antagonist |
| Biological Activity | Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. |
| Areas of Interest | Hereditary angioedema |
| Functions | Type 1 angiotensin receptor binding |
| Disease | Hereditary angioneurotic edema |
| Target | Bradykinin Receptor |
| Source# | Synthetic |
Storage | -20°C |
Solubility | Soluble in DMSO. |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Long-term Storage Conditions | -20 °C |
Organism | Human |
BoilingPoint | N/A |
ShelfLife | >2 years if stored properly |
Melting Point | N/A |
| CAT# |
Product Name |
M.W |
Molecular Formula |
Inquiry |
| 10-101-160 |
Ecallantide |
7053.83 |
C305H442N88O91S8 |
Inquiry |
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