High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM) that exhibits >20,000-fold selectivity for NPR3 over NPR1.
CAT# | R0974 |
CAS | 124833-45-0 |
Synonyms/Alias | N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-[(2S)-2-methylbutyl]-L-argininamide; (S)-N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-(2-methylbutyl)-L-argininamide; AP 811; |
M.F/Formula | C46H66N12O8 |
M.W/Mr. | 915.1 |
Sequence | RIDR(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide) |
Labeling Target | ANP clearance receptor (NPR3) |
Activity | Antagonist |
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