Selective and potent antagonist of corticotropin-releasing factor receptor 2 (CRF2) (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively) that antagonizes CRF2-mediated inhibition of gastric emptying.
CAT# | R1100 |
CAS | 681260-70-8 |
M.F/Formula | C183H307N49O53 |
M.W/Mr. | 4041.69 |
Sequence | DLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI(Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Lactam Bridge = Glu-24 - Lys-27) |
Labeling Target | Corticotropin-releasing factor receptor 2 (CRF2) |
Appearance | White lyophilised solid |
Purity | >98% |
Activity | Antagonist |
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