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CAT# | Product Name | M.W | Molecular Formula | Inquiry |
---|---|---|---|---|
B1801 | [Tyr0] BNP (1-32), human | 3627.3 | C152H253N51O44S4 | Inquiry |
B1802 | Biotinyl-BNP-32 (human) trifluoroacetate salt | 3690.39 | C₁₅₃H₂₅₈N₅₂O₄₄S₅ | Inquiry |
B1804 | BNP (1-32), porcine | 3570.15 | C₁₄₉H₂₅₀N₅₂O₄₄S₃ | Inquiry |
B1806 | BNP (1-45), mouse | 4919.61 | C₂₀₉H₃₅₄N₇₀O₆₃S₂ | Inquiry |
B1808 | BNP (7-32), porcine | 2869.3 | C120H198N42O36S2 | Inquiry |
B1813 | BNP (64-95), rat | 3452 | Inquiry | |
B1814 | BNP-45 (51-95) rat 5K Cardiac Natriuretic Peptide | 5040.8 | Inquiry |
Brain natriuretic peptide (BNP), also known as B-type Natriuretic Peptide, brain natriuretic peptide, which is another member of the natriuretic peptide system after atrial natriuretic peptide (ANP). Because it was first separated from the pig brain in 1988 by the Japanese scholar Sudoh, in fact, it mainly comes from the ventricle. Like ANP, BNP has a ring structure composed of 17 amino acids through a pair of disulfide bonds, which is necessary for the binding of receptors, in which disulfide bonds are important for the bioactivity of BNP. BNP is species-specific. Rat BNP consists of 45 amino acids, while pig, dog and human BNP consists of 32 amino acids. The human BNP gene fragment is located at the distal end of the short arm of chromosome 1 and is connected to the upstream ANP fragment. Its reverse transcriptional deoxyribonucleic acid (cDNA) is composed of 1900 nucleotides, and the messenger ribonucleic acid (mRNA) of BNP is composed of 900 to 1000 nucleotides, which can be expressed as BNP precursor. The N-terminal signal peptide becomes (proBNP), a BNP precursor containing 108amino acids, but is not stored in secretory granules, but is mainly secreted from the ventricle. During its secretion or after entering the blood, it decomposes into bioactive BNP (C-terminal fragment containing 32 amino acids) and N-terminal fragment. The release of BNP was regulated by left ventricular extension and wall tension.
BNP has important pathophysiological significance. It can promote the excretion of sodium and urination, has a strong vasodilating effect, and can resist the vasoconstriction of renin-angiotensin-aldosterone system (RAAS). Like ANP, it is a major endocrine system to resist volume overload and hypertension. Cardiac dysfunction can greatly activate the natriuretic peptide system, and increased ventricular load leads to BNP release.
In conclusion, with the deepening of the study, the determination of plasma BNP concentration is likely to be an important supplement to the evaluation of cardiac function, and become a simple and convenient routine examination.
References
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