The peptide is a specific inhibitor for calcineurin phosphatase, and corresponds to the residues 467-491 within the inhibitory domain of human calcineurin alpha subunit. It inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 uM using 32P-myosin light chain as substrate), but does not affect Ni2+-stimulated enzyme activity.
CAT# | R0845 |
CAS | 148067-21-4 |
M.F/Formula | C124H205N39O39S2 |
M.W/Mr. | 2930.34 |
Sequence | ITSFEEAKGLDRINERMPPRRDAMP |
Labeling Target | Calcineurin |
Appearance | White to off white powder |
Purity | >98 % |
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