Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 1.21 nM). It can suppress production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland which inhibits ovulation, exhibit antiproliferative effects and display efficacy against hormone-sensitive cancers in vivo. It is often used to treat hormone-sensitive cancers of the prostate and breast.
CAT# | R0997 |
CAS | 145672-81-7 |
Synonyms/Alias | N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide Acetate; N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide Acetate; SB 075 Acetate |
M.F/Formula | C70H92ClN17O14.C2H4O2 |
M.W/Mr. | 1491.11 |
Sequence | XFASYXLRPA(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide) |
Labeling Target | Potent gonadotropin-releasing hormone (GnRH) receptor |
Application | Cetrorelix acetate is used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders. |
Appearance | White to off-white solid |
Purity | >98% |
Activity | Antagonist |
Biological Activity | Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. |
Areas of Interest | Hormonal therapy |
Target | Gonadotropin-releasing hormone receptor |
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