Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
CAT# | R1953 |
Chemical Structure | |
CAS | 199807-35-7 |
Synonyms/Alias | Cilengitide TFA;Cilengitide TFA salt; EMD-85189; EMD 85189; EMD85189; EMD-121974; EMD121974; EMD 121974; NSC-707544; D03497;cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl] trifluoroacetic acid |
Chemical Name | 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid |
M.F/Formula | C29H41F3N8O9 |
M.W/Mr. | 702.7 |
Sequence | cyclo[Arg-Gly-Asp-D-Phe-N(Me)Val].TFA |
Appearance | Solid powder |
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