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APIs

CAT#
10-101-132
Synonyms/Alias
Degarelix acetate; FirMagon; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-4-[2,6-dioxohexahydropyrimidin-4(S)-ylcarboxamido]-L-phenylalanyl-4-ureido-D-phenylalanyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetate
CAS No.
214766-78-6
Sequence
Ac-D-2-Nal-D-4-Cpa-D-3-Pal-Ser-4-aminoPhe(L-4,5-dihydroorotyl)-4-ureido-DPhe-Leu-Lys(isopropyl)-ProD-Ala-NH2.
M.W/Mr.
1632.28
Molecular Formula
C82H103ClN18O16
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
Advanced prostate cancer
Description
Degarelix (INN) or degarelix acetate (USAN) (trade name Firmagon) has an immediate onset of action, binding to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocking their interaction with GnRH. This induces a fast and profound reduction in luteinising hormone (LH), follicle-stimulating hormone (FSH) and in turn, testosterone suppression. Testosterone is a male hormone that promotes growth of many prostate tumours.
Areas of Interest
Hormonal therapy
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