DPDPE

DPDPE is a selective δ-opioid receptor agonist peptide that inhibits electrically stimulated contraction of mouse vas deferens in vitro and is antinociceptive in vivo. DPDPE is a heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond. It has a role as a delta-opioid receptor agonist.

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CAT#R1918
Chemical Structure
CAS88373-73-3
Synonyms/AliasDPDPE; [D-Pen2,5]Enkephalin; [D-Pen2,D-Pen5]Enkephalin
Chemical Name(4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
M.F/FormulaC30H39N5O7S2
M.W/Mr.645.79
SequenceOne Letter Code: YXGFX
Three Letter Code: H-Tyr-D-Pen(1)-Gly-Phe-D-Pen(1)-OH
ApplicationOpioid Research
AppearanceSolid powder
ActivityAgonist
Biological ActivityPrototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
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