MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM), and displays 4000-fold selectivity over cam kinase ii and does not inhibit PKA. It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ. MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.
CAT# | R0854 |
CAS | 224579-74-2 |
Synonyms/Alias | Myosin Light Chain Kinase Inhibitor Peptide 18 |
M.F/Formula | C60H105N23O11 |
M.W/Mr. | 1324.64 |
Sequence | RKKYKYRRK-NH2 |
Labeling Target | Myosin |
Appearance | Crystalline solid |
Purity | ≥95% |
Activity | Inhibitor |
Areas of Interest | Immunology & Inflammation Cell Biology |
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