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MM-102

MM-102 is a novel potent inhibitor of MLL1/WDR5 protein-protein interaction.

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CAT#R1919
Chemical Structure
CAS1417329-24-8
Synonyms/AliasMM-102; MM102; MM 102; HMTase Inhibitor IX
Chemical NameN-[bis(4-fluorophenyl)methyl]-1-[[(2S)-5-(diaminomethylideneamino)-2-[[2-ethyl-2-(2-methylpropanoylamino)butanoyl]amino]pentanoyl]amino]cyclopentane-1-carboxamide
M.F/FormulaC35H49F2N7O4
M.W/Mr.669.8
AppearanceSolid powder
Biological ActivityMM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.
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