Montirelin
Montirelin stimulates the release of thyrotropin and prolactin. It is synthesized by the neurons in the paraventricular nucleus of the hypothalamus. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the anterior pituitary gland.
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| CAT# | 10-101-64 |
| CAS | 62305-91-3 |
| Synonyms/Alias | CG 3703; CG-3703; CG3703; CNK 602A; CNK602A; CNK-602A; CNK 603; CNK603; CNK-603; NS-3; NS3; NS 3; PS 24; Montirelin; Montireline; Montirelinum; Montirelin; Montirelina; CCRIS 7571; CCRIS7571 |
| M.F/Formula | C17H24N6O4S |
| M.W/Mr. | 408.48 |
| Sequence | 6-Me-5-oxothiomorpholinyl-3-carbonyl-His-Pro-NH2 |
| Labeling Target | Thyrotrophin releasing hormone (TRH) receptor |
| Application | Montirelin is a potent, biologically stable TRH analog for brain receptor binding. |
| Activity | Agonist |
| Areas of Interest | Hormonal therapy |
| Disease | Seizures; Nerve trauma; Cognitive dysfunction; Sleep apnea |
| Source# | Synthetic |
Long-term Storage Conditions | −20°C |
InChI | InChI=1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)/t9?,11-,12?,13-/m0/s1 |
InChI Key | RSHMQGIMHQPMEB-VEEXIGFHSA-N |
Isomeric SMILES | CC1C(=O)NC(CS1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N |
BoilingPoint | 994.2±65.0 °C at 760 mmHg |
Melting Point | N/A |
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