Cell permeable, potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM), which exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. It inhibits NOX1-derived O2- production in HT-29 human colon cancer cells, and attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
CAT# | R1050 |
CAS | 1435893-78-9 |
M.F/Formula | C50H88N14O15 |
M.W/Mr. | 1125.33 |
Sequence | EPVDALGKAKV |
Labeling Target | NADPH oxidase 1 (NOX1) |
Activity | Inhibitor |
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