PDGFR740Y-P
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.
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| CAT# | R0897 |
| Chemical Structure |  |
| CAS | 1236188-16-1 |
| Synonyms/Alias | 40YPDGFR; PDGFR 740Y-P |
| M.F/Formula | C141H222N43O39PS3 |
| M.W/Mr. | 3270.72 |
| Sequence | One Letter Code: RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS
Three Letter Code: Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{PO2-Tyr}-Met-Asp-Met-Ser |
| Biological Activity | Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. |
| Storage | Desiccate at -20°C |
Solubility | Soluble to 1 mg/ml in water |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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