PMX 205

Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.

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CAT#	10-101-154
CAS	514814-49-4
Synonyms/Alias	PMX-205;Hydrocinnamate
M.F/Formula	C45H62N10O6
M.W/Mr.	839.05
Sequence	Cyclo[N2-(1-Oxo-3-phenylpropyl)-Orn-Pro-D-Cha-Trp-Arg]
Labeling Target	Complement C5a receptor
Application	PMX-205 is a potent antagonist of C5a receptor. It is used as anti-inflammatory drug.
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Agonist
Biological Activity	PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM).
Areas of Interest	Alzheimer's Disease,Anti-inflammatory
Functions	Toxic substance binding
Disease	Irritable bowel syndrome Chronic idiopathic constipation Irritable bowel syndrome characterized by constipation

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-180	Solanezumab	144000.1g/mol	C6396H9922N1712O1996S42	Inquiry
10-101-91	Neuropeptide Y (human, rat) Acetate	4271.74	C189H285N55O57S	Inquiry

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-20	Goserelin Acetate	1269.43	C59H84N18O14	Inquiry
10-101-59	Liraglutide	3751.2	C172H265N43O51	Inquiry
R1574	Octreotide	1019.24	C₄₉H₆₆N₁₀O₁₀S₂	Inquiry
10-101-139	Myrcludex B			Inquiry
10-101-285	Teduglutide	3752.08	C164H252N44O55S	Inquiry
R1847	Sermaglutide	4114	C187H291N45O59	Inquiry
R1961	Carbetocin	988.2	C45H69N11O12S	Inquiry

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Source#	Synthetic
Storage	-20°C
Solubility	Soluble in DMSO.
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
Organism	Human
InChI	InChI=1S/C45H62N10O6/c46-45(47)49-24-9-18-34-40(57)48-23-10-19-35(51-39(56)22-21-29-12-3-1-4-13-29)44(61)55-25-11-20-38(55)43(60)54-36(26-30-14-5-2-6-15-30)41(58)53-37(42(59)52-34)27-31-28-50-33-17-8-7-16-32(31)33/h1,3-4,7-8,12-13,16-17,28,30,34-38,50H,2,5-6,9-11,14-15,18-27H2,(H,48,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,46,47,49)/t34-,35-,36+,37-,38-/m0/s1
InChI Key	VATFHFJULBPYLM-ILOBPARPSA-N
Isomeric SMILES	C1CCC(CC1)C[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)NCCC[C@@H](C(=O)N3CCC[C@H]3C(=O)N2)NC(=O)CCC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65
BoilingPoint	N/A
ShelfLife	>2 years if stored properly
Melting Point	N/A