The undecapeptide substance P has a number of peripheral actions which include contraction of smooth muscle, reduction of blood pressure and stimulation of secretory tissues. Substance P also occurs in neurones in the central nervous system. It is of particular interest as a possible neurotransmitter or neuromodulator, released by primary sensory neurones.
CAT# | 10-101-52 |
CAS | 33507-63-0 (net) |
Synonyms/Alias | Euler-Gaddum Substance P; Hypothalamic Substance P; SP(1-11); SP1-11; SP 1-11; SP |
M.F/Formula | C63H98N18O13S |
M.W/Mr. | 1347.63 |
Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
Labeling Target | Neurokinin Receptor |
Application | Substance P is a modulator of pain transmission. As an extremely potent vasodilator, it produces significant bronchodilation in normal and asthmatic subjects and a maximal increase in forearm blood flow. |
Activity | Modulator |
Areas of Interest | Neurological Disease |
Target | Neurokinin Receptor |
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
Enfuvirtide, also named pentafuside, is an HIV fusion inhibitor originated at Duke University, where researchers ...
Perindopril erbumine is an angiotensioncon vertingenzyme (ACE) inhibitor without sulfhydryl group. It is a chi ...
BIO 1211, is a non-covalent, small-molecule, cyclohexanecarboxylic acid base compound, tight-binding inhibitor ( ...
Insulin was discovered by Banting and Best in 1921. Soon afterwards manufacturing processes were developed to extract the ins ...
Corticotropin-releasing factor (CRF) is a 41 amino acid peptide that is an important hormone in the hypothalamic ...