TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces the tubularization of hypoxic HUVECs.
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| CAT# | GR1228 |
| CAS | 1446322-66-2 |
| M.F/Formula | C111H188N42O24S2 |
| M.W/Mr. | 2559.1 |
| Sequence | One Letter Code: CLLFVY CGRKKRRQRRRPPQ*(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
Three Letter Code: Cys-Leu-Leu-Phe-Val-Tyr-Cys-Gly-Arg-Lys-Lys-Gln-Arg-Arg-Arg-Pro-Pro-Gln |
| Purity | >98 % |
| Storage | -20°C |
Solubility | Soluble to 1 mg/ml in water |
Shipping Condition | +20°C (International: -20°C) |
InChI Key | AWUUHEHYNQGEFC-XLZVTALKSA-N |
Canonical SMILES | CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(C)C)CSSCC(C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CCC(=O)N)C(=O)O)N)CC4=CC=C(C=C4)O)C(C)C)CC5=CC=CC=C5 |
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