GPS1573 is a newly described potent and dose-dependent peptide antagonist of ACTH-stimulated melanocortin type 2 receptor (MC2R) activity in vitro (IC50 = 66 nM). GPS1573 antagonizes MC4R with IC50 of 950 nM, therefore showing selectivity for MC2R. The binding of ACTH to MC2R regulates steroidogenesis leading to metabolic diseases such as Cushing's disease in patients with pituitary dysfunctions.
CAT# | A03042 |
Synonyms/Alias | GPS1573; MC2R antagonist; Adrenocorticotropic hormone receptor antagonist |
M.F/Formula | C86H139N27O16 |
M.W/Mr. | 1807 |
Sequence | Three-Letter Code: H-Nle-Pro-(D-Phe)-Arg-(D-Trp)-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 One-Letter Code: H-Nle-PfRwFKAVGKKRR-NH2 |
Purity | Purity > 95% by HPLC |
* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).
Creative Peptides has accumulated a huge library of peptide knowledge including frontier peptide articles, application of peptides, useful tools, and more!
Ornithoctonus huwena, Chinese tarantula, is one of the most venomous spiders in China, and its venom can kill in ...
st-Ht31, a protein kinase A (PKA)-anchoring inhibitor, greatly induces robust cholesterol or phospholipid effl ...
The cyclopentapeptide FC 131 (cyclo(-L-Arg1-L-Arg2-L-2-Nal3-Gly4-D-Tyr5-), 2-Nal=3-(2-naphthyl) alanine)) is an ...
Basic Fibroblast Growth Factor, Human, called basic fibroblast growth factor (bFGF/FGF-b/FGF-2), is a single cha ...
Carnosine (β-alanyl-l-histidine), containing an imidazole moiety, is an intramuscular dipeptide consisting of β ...