A novel selective Nav1.7 channel blocker (IC50 = 2.5 nM). ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors.
CAT# | R0972 |
M.F/Formula | C162H246N52O43S6 |
M.W/Mr. | 3802.41 |
Sequence | DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2(Disulfide bridge: Cys2 and Cys17, Cys9 and Cys22, Cys16 and Cys29) |
Labeling Target | Nav1.7 channel |
Appearance | White lyophilized solid |
Purity | >98% |
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