TPT; SKF-104864A; SKFS-104864-A; 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin · HCl; (S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2b]quinoline-3,14(4H,12H)-dione · HCl; (20S)-10-Dimethylaminomethyl-4-ethyl
123948-87-8 (net), 119413-54-6 (hydrochloride)
Ovarian cancer & Cervical cancer & Small cell lung cancer (SCLC)
Topotecan Hydrochloride is the water-soluble hydrochloride salt preparation of Topotecan, a potent inhibitor of topoisomerase 1, and an apoptosis inducer, producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid camptothecin. It is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.
Areas of Interest