Trandolapril

Trandolapril is a prodrug that is de-esterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system.

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CAT#	10-101-125
CAS	87679-37-6
Synonyms/Alias	RU 44570; (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] hexahydro-2-indolinecarboxylic acid 1-ethyl ester
M.F/Formula	C24H34N2O5
M.W/Mr.	430.53
Labeling Target	Angiotensin-converting Enzyme (ACE)
Application	Trandolapril is an ACE inhibitor used to treat high blood pressure and other conditions.
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Inhibitor
Biological Activity	Trandolapril is an ACE inhibitor used to treat high blood pressure. It acts by competitive inhibition of angiotensin converting enzyme (ACE), a key enzyme in the renin-angiotensin system which plays an important role in regulating blood pressure.
Areas of Interest	Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones
Functions	Vasopressin receptor activity
Target	Angiotensin-converting Enzyme (ACE)

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Source#	Synthetic
Solubility	Soluble in DMSO, not in water
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
Organism	Human
InChI	InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
InChI Key	VXFJYXUZANRPDJ-WTNASJBWSA-N
Isomeric SMILES	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O
BoilingPoint	626.0±55.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	122-123°C