Xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts.
CAT# | 10-101-127 |
CAS | 14293-44-8 |
Synonyms/Alias | Be-1293; MJF 10938; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoyl-benzamide; 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide |
M.F/Formula | C15H15ClN2O4S |
M.W/Mr. | 354.8 |
Labeling Target | Carbonic anyydrase (CA) |
Application | Xipamide (marketed under the tradename Aquaphor and Aquaphoril) is a sulfonamide diuretic drug. It is used for the treatment of oedema and hypertension. |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Agonist |
Biological Activity | Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE). |
Areas of Interest | Hypertension & Edema |
Functions | Toxic substance binding |
Disease | Irritable bowel syndrome Chronic idiopathic constipation Irritable bowel syndrome characterized by constipation |
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