Lecirelin (6-(3-methyl-d-valine)-9-(N-ethyl-L-prolynamide)-10-deglycinamide) luteinizing hormone releasing factor, is a synthetic hypothalamic gonadotropin releasing hormone (GnRH) analogue. Lecirelin is a nonapeptide, while the natural compound is a decapeptide. Moreover, the glycine aminoacid in the 6th position has been substituted by leucine.
CAT# | 10-101-89 |
Chemical Structure | |
CAS | 61012-19-9 |
Synonyms/Alias | (D-Tle6)-Leuprolide; (D-Tle6)-Leuprorelin; Dalmarelin; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-2-tert-butyl-D-glycyl-L-leucyl-L-arginyl-L-proline ethylamide |
Chemical Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
M.F/Formula | C59H84N16O12 |
M.W/Mr. | 1209.42 |
Sequence | Three Letter Code: pGlu-His-Trp-Ser-Tyr-D-tertLeu-Leu-Arg-Pro-NHEt |
Activity | Agonist |
Biological Activity | Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analogue, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts. |
Target | GnRH Receptor |
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