Rotigaptide

Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.

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CAT#10-101-55
CAS355151-12-1
Synonyms/AliasCHEMBL450656; GAP-486; ZP-123; ZP 123; ZP123 peptide; ZP-123 (ZEALAND); acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide; GAP486; GAP 486; Rotigaptide.
M.F/FormulaC28H39N7O9
M.W/Mr.617.65
SequenceAc-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
Labeling TargetGap junction modulator
ApplicationRotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityRotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial.
Areas of InterestCardiovascular System & Diseases
Pituitary & Hypothalamic Hormones
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