Rotigaptide

Name: Rotigaptide
Brand: Creative Peptides
SKU: 10-101-55
Availability: MadeToOrder

Rotigaptide, also called ZP-123, is a peptide analog, which has been shown to increase gap junction intercellular conductance in cardiac muscle cells. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm.

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CAT No: 10-101-55

CAS No: 355151-12-1

Synonyms/Alias: Rotigaptide;355151-12-1;ZP-123;ZP-123 (ZEALAND);GAP (WYETH);UNII-GFA1W6KO7N;GFA1W6KO7N;Rotigaptide [USAN:INN];Rotigaptide [USAN];rotigaptida;GAP 484;GAP 486;ZP123;ZP 123;Rotigaptide (USAN);ROTIGAPTIDE [INN];(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide;Ac-d-Tyr-d-Pro-d-Hyp-Gly-d-Ala-Gly-NH2;Glycinamide, N-acetyl-D-tyrosyl-D-prolyl-(4S)-4-hydroxy-D-prolylglycyl-D-alanyl-;Dipeptide 9f [PMID 19175320];Dipeptide 9f (PMID 19175320);CHEMBL450656;rotigaptidum;GAP-486;(2R)-N-(carbamoylmethyl)-2-(2-(((2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-4-hydroxypyrrolidin-2-yl)formamido)acetamido)propanamide;(2R)-N-(carbamoylmethyl)-2-(2-{[(2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidin-2-yl]formamido}acetamido)propanamide;(2R,4S)-1-((2R)-1-((2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carbonyl)-N-(2-(((2R)-1-((2-amino-2-oxoethyl)amino)-1-oxopropan-2-yl)amino)-2-oxoethyl)-4-hydroxypyrrolidine-2-carboxamide;ZP123 peptide;zp1-23;GTPL9214;DTXCID10111515;CHEBI:230093;Ac-Tyr-Pro-Hyp-Gly-Ala-Gly-NH2;AKOS040742576;DB13067;DA-67291;MS-30756;HY-106225;CS-0025346;NS00071051;D05767;G17110;Q7370547;acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide;N-Acetyl-d-tyrosyl-d-prolyl-(4S)-4-hydroxy-d-prolylglycyl-d-alanylglycinamide;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C28H39N7O9
M.W/Mr.	617.7
Sequence	One Letter Code:YPXGAG Three Letter Code:Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
Labeling Target	Gap junction modulator
Application	Rotigaptide is currently under clinical investigation for the treatment of cardiac arrhythmias–specifically atrial fibrillation.
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Biological Activity	Rotigaptide, also known as GAP-486; ZP-123, is a gap junction modulator potentially for the treatment of ventricular tachycardia and atrial.
Areas of Interest	Cardiovascular System & Diseases Pituitary & Hypothalamic Hormones

Long-term Storage Conditions	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Solubility	-20 °C
InChI	InChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
InChI Key	GFJRASPBQLDRRY-TWTQBQJDSA-N
BoilingPoint	1187.3±65.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
Melting Point	N/A

1. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

2. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis

3. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

4. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes

5. C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients

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