“Peptide synthesis” encompasses the preparation of a wide range of substances, from simple small-molecule peptides to large proteins. Bruce Merrifield’s pioneering introduction of solid-phase peptide synthesis (SPPS) fundamentally transformed peptide synthesis strategies …
The cyclic structure of macrocyclic peptides not only confers high binding affinity and molecular stability but also overcomes key challenges faced by traditional peptides, such as enzymatic degradation and low oral …
The cell membrane is a natural barrier composed of a lipid bilayer, which restricts the entry of external substances into the cell and ensures the stability of the intracellular environment. …
The biological activity of peptides is regulated through their binding to corresponding receptors. Peptides that target receptors overexpressed on tumor cells—but not on normal cells—are excellent candidates for in vivo tumor …
In recent years, anti-tumor peptides have emerged as a research hotspot in the biomedical field due to their unique molecular properties and broad therapeutic potential. Compared to traditional chemotherapy drugs, …
Peptides are functional nutrients that are the most active, easily absorbed, and capable of stimulating the body’s regeneration system, positioned between large protein molecules and small amino acids. They are …
Peptide synthesis, particularly solid-phase peptide synthesis (SPPS), is a widely employed method for creating peptides of varying lengths and sequences. The process has revolutionized the ability to produce synthetic peptides …
What is Trofinetide? Trofinetide is a synthetic glycine-proline-glutamic acid (GPE) tripeptide analogue derived from the N-terminal sequence of insulin-like growth factor 1 (IGF-1). It is primarily used to treat Rett …
As early as the 80s of the last century (1983), the exploration of oral delivery of peptides has achieved a historic breakthrough through cyclosporine A (Fig.1). This natural peptide can achieve …
Non-Ribosomal Peptide Synthetases (NRPSs) Non-ribosomal peptide synthesis is a universal and critical biochemical process catalyzed by NRPSs in bacteria and fungi, through which a wide array of therapeutically important peptides with …