In recent years, anti-tumor peptides have emerged as a research hotspot in the biomedical field due to their unique molecular properties and broad therapeutic potential. Compared to traditional chemotherapy drugs, …
What is Trofinetide? Trofinetide is a synthetic glycine-proline-glutamic acid (GPE) tripeptide analogue derived from the N-terminal sequence of insulin-like growth factor 1 (IGF-1). It is primarily used to treat Rett …
In the field of weight loss drug development, the recently disclosed clinical data of Amgen’s weight loss candidate drug Maridebart Cafraglutide (referred to as MariTide, formerly known as AMG 133) …
Synthesis of peptides is a complex process that usually involves different synthesis strategies and techniques. The following are some common approaches to peptide synthesis processes and techniques: Solid-Phase Synthesis This is one …
The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug …
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases. Traditional vaccines …
Cyclopeptides represent one of the most diverse architectures in current drug discovery efforts. Their small size, stability, and ease of synthesis provide an attractive scaffold for targeting and modulating some …
The FDA’s Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth …
Advantages of Peptides Peptides are a class of compounds formed by linking multiple amino acids through amide bonds, and their molecular size is between small molecule chemical drugs and macromolecular biological …
Background Peptide drugs, as a type of pharmaceutical with molecular weight between small molecule chemical drugs and biopolymers, provide more options for medicinal chemists and have become a hot research …