How do you get peptides into cells?
As early as the 80s of the last century (1983), the exploration of oral delivery of peptides has achieved a historic breakthrough through cyclosporine A (Fig.1). This natural peptide can achieve …
Cyclic Peptide Synthesis Strategies in Drug Development
Compared to linear peptides, cyclic peptides exhibit excellent biocompatibility and chemical diversity, making them effective in overcoming limitations and playing a crucial role in new drug development. In recent years, …
Classification of Impurities in Synthetic Peptide Drugs
Advantages of Peptides Peptides are a class of compounds formed by linking multiple amino acids through amide bonds, and their molecular size is between small molecule chemical drugs and macromolecular biological …
Plant Protein-Derived Antioxidant Peptides: An Overview
Background In recent years, more and more studies have described the antioxidant capacity of plant protein-derived peptides. Plant proteins are considered a new source of antioxidant peptides that can not …
An Overview of Peptidomimetics-the Antiviral Drugs
Antiviral drugs Antiviral drugs are a class of drugs used to treat viral infections. While most antiviral drugs target specific viruses, broad-spectrum antivirals are effective against multiple viruses. Most of …
Peptides for Gastrointestinal Studies
The gastrointestinal tract is the largest immune organ in the human body. The gastrointestinal tract refers to the digestive tract from the gastric pylorus to the anus, including the stomach, …
Drug Development of Intranasally Delivered Peptides
Intranasal (IN, intranasal) delivery of peptides has received considerable attention as a potential non-invasive delivery route through which peptide drugs can easily enter systemic circulation. Nasal delivery offers several advantages, …
Introduction to Peptide-based Checkpoint Inhibitors for Anti-Tumor
Background Recently, FDA approved the dual immunotherapy treatment for hepatocellular carcinoma with Astrazeneca’s Imjudo (tremelimumab) combined with Imfinzi (durvalumab), marking the second time of this year for the authoritative approval …
Brief Introduction to Covalent Peptide Drug Development
The effect of drugs is achieved by interfering with the pathogenic process by binding between drug molecules and receptors. The binding between the drug and the receptor protein, in addition …
Overview of Anti-Tumor Peptide Drugs
Peptide-based drug design has attracted much interest with the rapid growth of bioinformatics knowledge related to peptides and proteins. In the past, peptide-based drugs were not widely used due to …