“Peptide synthesis” encompasses the preparation of a wide range of substances, from simple small-molecule peptides to large proteins. Bruce Merrifield’s pioneering introduction of solid-phase peptide synthesis (SPPS) fundamentally transformed peptide synthesis strategies …
The cyclic structure of macrocyclic peptides not only confers high binding affinity and molecular stability but also overcomes key challenges faced by traditional peptides, such as enzymatic degradation and low oral …
The cell membrane is a natural barrier composed of a lipid bilayer, which restricts the entry of external substances into the cell and ensures the stability of the intracellular environment. …
The biological activity of peptides is regulated through their binding to corresponding receptors. Peptides that target receptors overexpressed on tumor cells—but not on normal cells—are excellent candidates for in vivo tumor …
Non-Ribosomal Peptide Synthetases (NRPSs) Non-ribosomal peptide synthesis is a universal and critical biochemical process catalyzed by NRPSs in bacteria and fungi, through which a wide array of therapeutically important peptides with …
The cytotoxin a-amanitin is a bicyclic octapeptide occurring in high concentrations in the deadly, poisonous mushroom Amanita phalloides. The primary cytopathogenicity of the amatoxins is the inhibition of RNA polymerase …
Blood consists of red and white cells which, along with platelets, are all suspended in plasma. All peripheral blood cells are derived from a single cell type: the stem cell …
All creatures, from the simplest viruses to humans, have complex protein structures that are made up of the same 20 amino acids. In the process of studying the proteins, biologists …
For drugs, the package insert is just as people’s “birth certificate”; it’s the certification all the drugs should carry when they are listed, which contains the most basic and important …
Pharmacological Effects: 1. It can inhibit the growth hormone, thyroid stimulating hormone, insulin, and pancreatic glucagon secretion. 2. It can inhibit gastric acid secretion stimulated by the test meal and …