Structure and function of amyloid
The term ‘amyloid’ was first used in 1854 by Rudolph Virchow to describe abnormal brain tissue that was stained by iodine, suggesting that it was starch-like. It was later discovered that the amyloid …
Therapeutic Peptides
Peptides & Proteins as Therapuetics The most frequently used peptide/protein drugs can be classified in three main groups. Group I includes exogenously administered protein drugs in case of a deficiency. …
Formation of a Single Phosphodiester Bond
The cytotoxin a-amanitin is a bicyclic octapeptide occurring in high concentrations in the deadly, poisonous mushroom Amanita phalloides. The primary cytopathogenicity of the amatoxins is the inhibition of RNA polymerase …
Haemopoietic growth factors
Blood consists of red and white cells which, along with platelets, are all suspended in plasma. All peripheral blood cells are derived from a single cell type: the stem cell …
Growth factors
The growth of eukaryotic cells is modulated by various influences, of which growth factors are amongst the most important for many cell types. A wide range of polypeptide growth factors …
The Research History of Peptide
All creatures, from the simplest viruses to humans, have complex protein structures that are made up of the same 20 amino acids. In the process of studying the proteins, biologists …
Neuropeptide Y
Neuropeptide Y (NPY) is a 36 amino acid, C-terminally amidated peptide. It is called Neuropeptide (Y) due to its abundance in the central and peripheral nervous system, and its high number …
FDA approved ALM201 for ovarian cancer
Ovarian cancer is caused by one kind of malignant tumor of ovarian neoplasms, which refers to malignant tumor cells surviving on women’s ovaries. 90%~95% of those tumor cells induce primary …
Broccoli Reduces Blood Sugar levels for diabetic people
Broccoli is a good food source of chromium, as one cup cooked broccoli contains 22 micrograms of chromium, 10 times that other food contains. Chromium plays an important role in …
Bacterial peptide deformylase inhibitor PMT analogs inhibit cancer cell growth by interacting with human peptide deformylase
The peptide deformylase (PDF) is a unique feature of prokaryotes and believed not to exist in eukaryotes up to even only a few years ago. PDF is essential for ribosomal …