Peptide Therapies in Diabetes Mellitus
Diabetes mellitus is a metabolic syndrome that is defined by raised plasma glucose levels, accompanied by complete or partial deficiency of insulin. Type II diabetes contributes to more than 90 % of …
Protein and Peptide Analysis
Protein and peptide analysis employs many different tools to identify and characterize the immense variety of proteins that are expressed in a cell of any organism. Traditionally, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) …
Structure and function of amyloid
The term ‘amyloid’ was first used in 1854 by Rudolph Virchow to describe abnormal brain tissue that was stained by iodine, suggesting that it was starch-like. It was later discovered that the amyloid …
Therapeutic Peptides
Peptides & Proteins as Therapuetics The most frequently used peptide/protein drugs can be classified in three main groups. Group I includes exogenously administered protein drugs in case of a deficiency. …
Formation of a Single Phosphodiester Bond
The cytotoxin a-amanitin is a bicyclic octapeptide occurring in high concentrations in the deadly, poisonous mushroom Amanita phalloides. The primary cytopathogenicity of the amatoxins is the inhibition of RNA polymerase …
Haemopoietic growth factors
Blood consists of red and white cells which, along with platelets, are all suspended in plasma. All peripheral blood cells are derived from a single cell type: the stem cell …
Growth factors
The growth of eukaryotic cells is modulated by various influences, of which growth factors are amongst the most important for many cell types. A wide range of polypeptide growth factors …
The Research History of Peptide
All creatures, from the simplest viruses to humans, have complex protein structures that are made up of the same 20 amino acids. In the process of studying the proteins, biologists …
Neuropeptide Y
Neuropeptide Y (NPY) is a 36 amino acid, C-terminally amidated peptide. It is called Neuropeptide (Y) due to its abundance in the central and peripheral nervous system, and its high number …
FDA approved ALM201 for ovarian cancer
Ovarian cancer is caused by one kind of malignant tumor of ovarian neoplasms, which refers to malignant tumor cells surviving on women’s ovaries. 90%~95% of those tumor cells induce primary …